We herein FLAX report on the synthesis of a pentacyclic triterpene functionalized through derivation of betulinic acid with hydroxybenzotriazole.The compound was fully characterized by proton (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum coherence (HSQC) and distortionless enhancement by polarization transfer (DEPT-135 and DEPT-90) nuclear magnetic resonance.Ultraviolet (UV), and Fourier-transform infrared (FTIR) spectroscopies as well as and high-resolution mass spectrometry (HRMS) were also adopted.Computational studies were conducted to foresee the interactions between compound 3 Caster Base and phosphodiesterase 9, a relevant target in the field of neurodegenerative diseases.Additionally, preliminary calculation of physico-chemical descriptors was performed to evaluate the drug-likeness of compound 3.